Identification of protein–protein interactions (PPIs) is at the center of molecular biology
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …

Most proteins perform their biological function by interacting with themselves or other
molecules. Thus, one may obtain biological insights into protein functions, disease …

We discuss basic physical–chemical principles underlying the formation of stable
macromolecular complexes, which in many cases are likely to be the biological units …

Proteins are the working horse of the cellular machinery. They are responsible for diverse
functions ranging from molecular motors to signaling. They catalyze reactions, transport …

Structurally conserved residues at protein–protein interfaces correlate with the experimental
alanine-scanning hot spots. Here, we investigate the organization of these conserved …

Transient complexes are crucial for diverse biological processes such as biochemical
pathways and signaling cascades in the cell. Here, we give an overview of the transient …

Proteins interact with each other in a highly specific manner, and protein interactions play a
key role in many cellular processes; in particular, the distortion of protein interfaces may lead …

Arginine is an abundant residue in protein–protein interfaces. The importance of this residue
relates to the versatility of its side chain in intermolecular interactions. Different classes of …

Prediction of protein-protein interactions at the structural level on the proteome scale is
important because it allows prediction of protein function, helps drug discovery and takes …

The assumption that crystal contacts reflect natural macromolecular interactions makes a
basis for many studies in structural biology. However, the crystal state may correspond to a …