The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Purpose of review: increasing evidence suggests that besides the several metabolic,
endocrine, and immune functions of 1alpha, 25-dihydroxyvitamin D (1, 25 (OH) 2D), the …

The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

During prion disease, an increase in misfolded prion protein (PrP) generated by prion
replication leads to sustained overactivation of the branch of the unfolded protein response …

The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a
multifunctional protein with activities far beyond its well-known role in the unfolded protein …

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a
cellular stress induced by multiple stimuli and pathological conditions. These include …

Proteins synthesized in the endoplasmic reticulum (ER) are properly folded with the
assistance of ER chaperones. Malfolded proteins are disposed of by ER‐associated protein …

The common underlying feature of most neurodegenerative diseases such as Alzheimer
disease (AD), prion diseases, Parkinson disease (PD), and amyotrophic lateral sclerosis …