Horizontal gene transfer of antibiotic resistance genes in biofilms

C Michaelis, E Grohmann - Antibiotics, 2023 - mdpi.com
Most bacteria attach to biotic or abiotic surfaces and are embedded in a complex matrix
which is known as biofilm. Biofilm formation is especially worrisome in clinical settings as it …

Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era

S Castañeda-Barba, EM Top, T Stalder - Nature Reviews Microbiology, 2024 - nature.com
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

mobileOG-db: a manually curated database of protein families mediating the life cycle of bacterial mobile genetic elements

CL Brown, J Mullet, F Hindi, JE Stoll… - Applied and …, 2022 - journals.asm.org
Bacterial mobile genetic elements (MGEs) encode functional modules that perform both core
and accessory functions for the element, the latter of which are often only transiently …

[HTML][HTML] ARGs-OAP v3. 0: Antibiotic-resistance gene database curation and analysis pipeline optimization

X Yin, X Zheng, L Li, AN Zhang, XT Jiang, T Zhang - Engineering, 2023 - Elsevier
Antibiotic resistance, which is encoded by antibiotic-resistance genes (ARGs), has
proliferated to become a growing threat to public health around the world. With technical …

The evolution of antibiotic resistance islands occurs within the framework of plasmid lineages

Y Wang, T Dagan - Nature Communications, 2024 - nature.com
Bacterial pathogens carrying multidrug resistance (MDR) plasmids are a major threat to
human health. The acquisition of antibiotic resistance genes (ARGs) in plasmids is often …

Antibiotic resistance: A key microbial survival mechanism that threatens public health

A Abbas, A Barkhouse, D Hackenberger, GD Wright - Cell Host & Microbe, 2024 - cell.com
Antibiotic resistance (AMR) is a global public health threat, challenging the effectiveness of
antibiotics in combating bacterial infections. AMR also represents one of the most crucial …

Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens

X Wang, H Zhang, S Yu, D Li, MR Gillings… - The ISME …, 2024 - academic.oup.com
Antimicrobial resistance is a major threat for public health. Plasmids play a critical role in the
spread of antimicrobial resistance via horizontal gene transfer between bacterial species …

Microbial evolution through horizontal gene transfer by mobile genetic elements

M Tokuda, M Shintani - Microbial Biotechnology, 2024 - Wiley Online Library
Mobile genetic elements (MGEs) are crucial for horizontal gene transfer (HGT) in bacteria
and facilitate their rapid evolution and adaptation. MGEs include plasmids, integrative and …

Phage-plasmids spread antibiotic resistance genes through infection and lysogenic conversion

E Pfeifer, RA Bonnin, EPC Rocha - MBio, 2022 - journals.asm.org
Antibiotic resistance is rapidly spreading via the horizontal transfer of resistance genes in
mobile genetic elements. While plasmids are key drivers of this process, few integrative …

Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria

R Maddamsetti, Y Yao, T Wang, J Gao… - Nature …, 2024 - nature.com
Horizontal gene transfer (HGT) and gene duplication are often considered as separate
mechanisms driving the evolution of new functions. However, the mobile genetic elements …