Horizontal gene transfer of antibiotic resistance genes in biofilms

C Michaelis, E Grohmann - Antibiotics, 2023 - mdpi.com
Most bacteria attach to biotic or abiotic surfaces and are embedded in a complex matrix
which is known as biofilm. Biofilm formation is especially worrisome in clinical settings as it …

Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era

S Castañeda-Barba, EM Top, T Stalder - Nature Reviews Microbiology, 2024 - nature.com
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

Mobile genetic element flexibility as an underlying principle to bacterial evolution

AJ Weisberg, JH Chang - Annual Review of Microbiology, 2023 - annualreviews.org
Mobile genetic elements are key to the evolution of bacteria and traits that affect host and
ecosystem health. Here, we use a framework of a hierarchical and modular system that …

[HTML][HTML] ARGs-OAP v3. 0: Antibiotic-resistance gene database curation and analysis pipeline optimization

X Yin, X Zheng, L Li, AN Zhang, XT Jiang, T Zhang - Engineering, 2023 - Elsevier
Antibiotic resistance, which is encoded by antibiotic-resistance genes (ARGs), has
proliferated to become a growing threat to public health around the world. With technical …

mobileOG-db: a manually curated database of protein families mediating the life cycle of bacterial mobile genetic elements

CL Brown, J Mullet, F Hindi, JE Stoll… - Applied and …, 2022 - Am Soc Microbiol
Bacterial mobile genetic elements (MGEs) encode functional modules that perform both core
and accessory functions for the element, the latter of which are often only transiently …

Evolution of plasmid mobility: origin and fate of conjugative and nonconjugative plasmids

C Coluzzi, MP Garcillán-Barcia… - Molecular Biology …, 2022 - academic.oup.com
Conjugation drives the horizontal transfer of adaptive traits across prokaryotes. One-fourth of
the plasmids encode the functions necessary to conjugate autonomously, the others being …

Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge

F Berglund, S Ebmeyer, E Kristiansson… - Communications …, 2023 - nature.com
The emergence and spread of mobile antibiotic resistance genes (ARGs) in pathogens have
become a serious threat to global health. Still little is known about where ARGs gain mobility …

Mating pair stabilization mediates bacterial conjugation species specificity

WW Low, JLC Wong, LC Beltran, C Seddon… - Nature …, 2022 - nature.com
Bacterial conjugation mediates contact-dependent transfer of DNA from donor to recipient
bacteria, thus facilitating the spread of virulence and resistance plasmids. Here we describe …

Phage-plasmids spread antibiotic resistance genes through infection and lysogenic conversion

E Pfeifer, RA Bonnin, EPC Rocha - MBio, 2022 - Am Soc Microbiol
Antibiotic resistance is rapidly spreading via the horizontal transfer of resistance genes in
mobile genetic elements. While plasmids are key drivers of this process, few integrative …

VRprofile2: detection of antibiotic resistance-associated mobilome in bacterial pathogens

M Wang, YX Goh, C Tai, H Wang, Z Deng… - Nucleic acids …, 2022 - academic.oup.com
VRprofile2 is an updated pipeline that rapidly identifies diverse mobile genetic elements in
bacterial genome sequences. Compared with the previous version, three major …