Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Several recent studies in a number of model systems including zebrafish, Arabidopsis, and
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …

DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

Modification of DNA bases plays vital roles in the epigenetic control of gene expression in
both animals and plants. Though much attention is given to the conventional epigenetic …

Summary N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger
RNAs and is linked to human diseases, but its functions in mammalian development are …

Mice carrying mutations in multiple genes are traditionally generated by sequential
recombination in embryonic stem cells and/or time-consuming intercrossing of mice with a …

DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …