Increasing antibiotic resistance in multidrug-resistant (MDR) Gram-negative bacteria (MDR-
GNB) presents significant health problems worldwide, since the vital available and effective …

Antibiotics changed medical practice by significantly decreasing the morbidity and mortality
associated with bacterial infection. However, infectious diseases remain the leading cause …

The spread of bacterial drug resistance has posed a severe threat to public health globally.
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …

SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …

The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

Antibiotic resistance is a public health problem of growing concern. Animal manure
application to soil is considered to be a main cause of the propagation and dissemination of …

Multidrug-resistant bacteria have on overwhelming impact on human health, as they cause
over 670,000 infections and 33,000 deaths annually in the European Union alone. Of these …

The emergence and spread of mobile colistin (COL) resistance (mcr) genes jeopardize the
efficacy of COL, a last resort antibiotic for treating deadly infections. COL has been used in …

Colistin resistance is a globalized sensible issue because it has been considered a drug of
the last‐line resort to treat drug‐resistant bacterial infections. The product of the mobilized …

Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-
negative bacteria. We report our experience with cefiderocol-based combination therapies …