Cellular function and molecular structure of ecto-nucleotidases
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
Multisystemic functions of alkaline phosphatases
Human and mouse alkaline phosphatases (AP) are encoded by a multigene family
expressed ubiquitously in multiple tissues. Gene knockout (KO) findings have helped define …
expressed ubiquitously in multiple tissues. Gene knockout (KO) findings have helped define …
[HTML][HTML] Hypophosphatasia: biological and clinical aspects, avenues for therapy
JP Salles - The Clinical Biochemist Reviews, 2020 - ncbi.nlm.nih.gov
Hypophosphatasia (HPP) is a rare inherited systemic metabolic disease caused by
mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene. TNSALP is …
mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene. TNSALP is …
Clinical and genetic aspects of hypophosphatasia in Japanese patients
T Taketani, K Onigata, H Kobayashi… - Archives of disease in …, 2014 - adc.bmj.com
Objective We examined the clinical and genetic features of hypophosphatasia (HPP) in
Japanese patients. HPP is a rare metabolic bone disorder of bone mineralisation caused by …
Japanese patients. HPP is a rare metabolic bone disorder of bone mineralisation caused by …
Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation
Hypomorphic mutations in the gene encoding the tissue-nonspecific alkaline phosphatase
(TNAP) enzyme, ALPL in human or Akp2 in mice, cause hypophosphatasia (HPP), an …
(TNAP) enzyme, ALPL in human or Akp2 in mice, cause hypophosphatasia (HPP), an …
Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease
ERLC Vardy, KAB Kellett, SL Cocklin… - Neurodegenerative …, 2011 - karger.com
Background: Tissue non-specific alkaline phosphatase (TNAP) has been shown to promote
the neurotoxicity of extracellular tau which contributes to the spread of pathology in …
the neurotoxicity of extracellular tau which contributes to the spread of pathology in …
[HTML][HTML] Tissue-nonspecific alkaline phosphatase regulates purinergic transmission in the central nervous system during development and disease
Tissue-nonspecific alkaline phosphatase (TNAP) is one of the four isozymes in humans and
mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of …
mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of …
A new perspective on the function of Tissue Non-Specific Alkaline Phosphatase: from bone mineralization to intra-cellular lipid accumulation
CL Bartlett, EM Cave, NJ Crowther… - Molecular and Cellular …, 2022 - Springer
Tissue-nonspecific alkaline phosphatase (TNAP) is one of four isozymes, which include
germ cell, placental and intestinal alkaline phosphatases. The TNAP isozyme has 3 isoforms …
germ cell, placental and intestinal alkaline phosphatases. The TNAP isozyme has 3 isoforms …
Tissue-Nonspecific alkaline Phosphatase—A gatekeeper of physiological conditions in health and a modulator of biological environments in disease
Tissue-nonspecific alkaline phosphatase (TNAP) is a ubiquitously expressed enzyme that is
best known for its role during mineralization processes in bones and skeleton. The enzyme …
best known for its role during mineralization processes in bones and skeleton. The enzyme …
Tissue-nonspecific alkaline phosphatase in central nervous system health and disease: a focus on brain microvascular endothelial cells
Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme bound to the plasma
membranes of numerous cells via a glycosylphosphatidylinositol (GPI) moiety. TNAP's …
membranes of numerous cells via a glycosylphosphatidylinositol (GPI) moiety. TNAP's …