Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y **a, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Application of marine natural products against Alzheimer's disease: past, present and future

D Hu, Y **, X Hou, Y Zhu, D Chen, J Tai, Q Chen… - Marine Drugs, 2023 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative disease, is one of the most intractable
illnesses which affects the elderly. Clinically manifested as various impairments in memory …

[HTML][HTML] Therapeutic potential of targeting mitochondria for Alzheimer's disease treatment

A Atlante, G Amadoro, V Latina, D Valenti - Journal of Clinical Medicine, 2022 - mdpi.com
Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, is
characterized by memory and cognitive impairment and by the accumulation in the brain of …

Natural alkaloids as multi-target compounds towards factors implicated in Alzheimer's disease

R Vrabec, G Blunden, L Cahlíková - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …

Molecular interactions, binding stability, and synergistic inhibition on Acetylcholinesterase activity of Safranin O in combination with Quercetin and Gallic acid: In vitro …

K Imededdine, WA Eltayb, A Boufissiou… - Journal of Molecular …, 2023 - Elsevier
The clinical management of multifactorial diseases, especially in neurodegenerative
disorders, requires the identification of potent synergistic interactions between therapeutic …

Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress

MN ALNasser, AM AlSaadi, A Whitby, DH Kim… - Life, 2023 - mdpi.com
Aberrant accumulation of the neurotransmitter L-glutamate (L-Glu) has been implicated as a
mechanism of neurodegeneration, and the release of L-Glu after stroke onset leads to a …

Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges

J Lü, C Jiang, TD Schell, M Joshi… - The American Journal …, 2022 - World Scientific
Angelica gigas Nakai (AGN) root is a medicinal herbal widely used in traditional medicine in
Korea. AGN root ethanolic extract dietary supplements are marketed in the United States for …

In silico design of dual-binding site anti-cholinesterase phytochemical heterodimers as treatment options for Alzheimer's disease

H Amat-ur-Rasool, M Ahmed, S Hasnain… - Current Issues in …, 2021 - mdpi.com
The number of patients with neurodegenerative diseases, particularly Alzheimer's disease
(AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line …

[HTML][HTML] A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease

MN ALNasser, IR Mellor, WG Carter - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) is characterised by progressive neuronal atrophy and the loss of
neuronal function as a consequence of multiple pathomechanisms. Current AD treatments …

Recent advances in potential enzymes and their therapeutic inhibitors for the treatment of Alzheimer's disease

ZF Vahid, M Eskandani, H Dadashi, S Vandghanooni… - Heliyon, 2024 - cell.com
Abstract Alzheimer's disease (AD), a chronic neurodegenerative disease, is clinically
characterized by loss of memory and learning ability among other neurological deficits …