Thermodynamics and Kinetics‐Directed Regulation of Nucleic Acid‐Based Molecular Recognition

Y Liu, Z Zhao, Y Zeng, M He, Y Lyu, Q Yuan - Small Methods, 2024 - Wiley Online Library
Nucleic acid‐based molecular recognition plays crucial roles in various fields like
biosensing and disease diagnostics. To achieve optimal detection and analysis, it is …

Programing chemical communication: allostery vs multivalent mechanism

D Lauzon, A Vallée-Bélisle - Journal of the American Chemical …, 2023 - ACS Publications
The emergence of life has relied on chemical communication and the ability to integrate
multiple chemical inputs into a specific output. Two mechanisms are typically employed by …

Programming the Dynamic Range of Nanochannel Biosensors for MicroRNA Detection Through Allosteric DNA Probes

Z Shang, D Ding, Z Deng, J Zhao, M Yang… - Angewandte …, 2024 - Wiley Online Library
Solid‐state nanochannel biosensors are extensively utilized for microRNA (miRNA)
detection owing to their high sensitivity and rapid response. However, conventional …

Engineering modular and tunable single-molecule sensors by decoupling sensing from signal output

L Grabenhorst, M Pfeiffer, T Schinkel… - Nature …, 2024 - nature.com
Biosensors play key roles in medical research and diagnostics. However, the development
of biosensors for new biomolecular targets of interest often involves tedious optimization …

[HTML][HTML] A novel magnetic ligand-based assay for the electrochemical determination of BRD4

S Fortunati, M Giannetto, F Pedrini, P Nikolaou… - Talanta, 2024 - Elsevier
The first magnetic ligand-based electrochemical assay aimed at the determination of BRD4
was developed and validated. BRD4 is an epigenetic regulator of great interest in oncology …

Adaptive molecular communication receivers with tunable ligand-receptor interactions

M Kuscu - arxiv preprint arxiv:2305.06481, 2023 - arxiv.org
Molecular Communications (MC) underpins signaling in biological systems, enabling
information transfer through biochemical molecules. The prospect of engineering this natural …

Variable gain DNA nanostructure charge amplifiers for biosensing

JM Majikes, S Cho, TE Cleveland, JA Liddle… - Nanoscale, 2024 - pubs.rsc.org
Electronic measurements of engineered nanostructures comprised solely of DNA (DNA
origami) enable new signal conditioning modalities for use in biosensing. DNA origami …

Advancements and Challenges in Aptamer-Based Therapeutics and Diagnostics Across Diverse Medical Domains: A Comprehensive Review

ASAA Agha, W Alshaer, T Aburjai - Jordan Journal of …, 2024 - jjournals.ju.edu.jo
Aptamers, which are single-stranded DNA or RNA molecules, are increasingly recognized
as important tools in diagnostics and therapeutics across various medical disciplines such …

Rationally Designed DNA-Based Scaffolds and Switching Probes for Protein Sensing

A Chamorro, M Rossetti, N Bagheri… - Trends in Biosensing …, 2024 - Springer
The detection of a protein analyte and use of this type of information for disease diagnosis
and physiological monitoring requires methods with high sensitivity and specificity that have …

Investigation of Indole Derivatives as Fluorescent Nucleobase Analogs for Mercury Sensing Using DNA Hairpins

D Roby - 2025 - atrium.lib.uoguelph.ca
Indole sparks interest for fluorescent sensing due to its customizability and environmental
sensitivity, enabling opportunities for diverse fluorescent probes. This motivates the …