As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …

Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome
instability to uncontrolled proliferation or invasion. Cancer cells are constantly challenged by …

Diverse tissues in vivo present varying degrees of confinement, constriction, and
compression to migrating cells in both homeostasis and disease. The nucleus in particular is …

All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Cell migration is a vital and dynamic process required for the development of multicellular
organisms and for immune system responses, tissue renewal and wound healing in adults. It …

To spread from a localized tumor, metastatic cancer cells must squeeze through
constrictions that cause major nuclear deformations. Since chromosome structure affects …

Metastasis remains the leading cause of cancer lethality. The'seed/soil'hypothesis provides
the framework to explain this cancer phenomenon where the concept of organotropism has …

Chromatin regulatory processes physically take place in the environment of the cell nucleus,
which is filled with the chromosomes and a plethora of smaller biomolecules. The nucleus …