In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian
target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been …

NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic
division of the cell. Over expression of NEK7 leads to the progression of different cancers …

NLRP3 inflammasome plays an essential role in innate immunity, yet the activation
mechanism of NLRP3 inflammasome is not clear. In human or animal models, inappropriate …

As an important aspect of computer-aided drug design, structure-based drug design brought
a new horizon to pharmaceutical development. This in silico method permeates all aspects …

NIMA-related kinases, or NEKs, are a family of Ser/Thr protein kinases involved in cell cycle
and mitosis, centrosome disjunction, primary cilia functions, and DNA damage responses …

Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere
chromatin structure and integrity. However, how telomere integrity is maintained, especially …

Simple Summary Kinases are biomolecules that control cellular reactions essential for life.
Disruptions in kinase expression and activity lead to the development of diseases such as …

Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis
regulation is the never in mitosis-gene A (NIMA)-related kinases (Neks). The founding …

The NIMA (never in mitosis, gene A)-related kinase-6 (NEK6), which is implicated in cell
cycle control and plays significant roles in tumorigenesis, is an attractive target for the …

Human NEK7 is a regulator of cell division and plays an important role in growth and
survival of mammalian cells. Human NEK6 and NEK7 are closely related, consisting of a …