Mental disorders represent a worldwide public health concern. Psychotherapies and
pharmacotherapies are recommended as first line treatments. However, evidence has …

Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

The Mental Health Gap Action Programme (mhGAP) guideline, published by the World
Health Organization in 2023, provides comprehensive strategies for addressing mental …

Background Bipolar depression constitutes a major public health problem due to its
substantial burden of disease. Although pharmacological interventions are available …

A systematic review and random-effects model network meta-analysis was conducted to
compare the efficacy, acceptability, tolerability, and safety of pharmacological interventions …

Objectives To understand treatment practices for bipolar disorders (BD), this study leveraged
the Global Bipolar Cohort collaborative network to investigate pharmacotherapeutic …

Depression is a severe mental health problem that affects people regardless of social status
or education, is associated with changes in mood and behavior, and can result in a suicide …

Background There are no recommendations based on the efficacy of specific drugs for the
treatment of psychotic depression. To address this evidence gap, we did a network meta …

Uncertainty remains regarding the relative efficacy of maintenance pharmacotherapy for
bipolar disorder (BD), and available data require updating. The present systematic review …

Since their first application in psychiatry seventy years ago, antipsychotic drugs, besides
schizophrenia, have been widely used in the treatment of mood disorders. Such an …