Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Our objective was to conduct a meta-analysis of therapeutic efficacy of pharmacological
treatment of adult ADHD based on data from controlled clinical trials. We used the search …

Stereospecific nucleophilic substitution was achieved for the first time with arylboronic acids
as nucleophiles. This transition‐metal‐free coupling between chiral α‐aryl‐α‐mesylated …

CYP2D6 accounts for only a small percentage of total hepatic CYPs (100) with significant
polymorphisms. A number of drugs acting on the central nervous system and cardiovascular …

A general synthesis of chiral α, α-diaryl carboxamides is developed by enantioselective
cross-coupling between 2-bromo-2-aryl carboxamides and arylboronic acids, leading to a …

Objective: This review examines and summarizes the pharmacodynamic and
pharmacokinetic properties, short-and longer-term efficacy, the moderating effect of …

To investigate the effect of the variant CYP2D6* 10 allele on the pharmacokinetics of
atomoxetine and its metabolites, 4-hydroxyatomoxetine (4-HAT) and N …

This pilot longitudinal study using measures from parents and teachers evaluated the effects
of flexible doses of atomoxetine (ATX) on neuropsychological and functional outcomes in 21 …

OBJECTIVE: The primary aim of this study was to assess the efficacy of atomoxetine in
improving ADHD and ODD symptoms in paediatric patients with ADHD and comorbid …

To determine whether physicians can adequately titrate atomoxetine without knowing
genotype status for hepatic cytochrome P450 2D6, we pooled data from two open-label …