Capillary-mitochondrial oxygen transport in muscle: paradigm shifts

DC Poole, TI Musch - Function, 2023‏ - academic.oup.com
When exercising humans increase their oxygen uptake (V̇O2) 20-fold above rest the
numbers are staggering: Each minute the O2 transport system-lungs, cardiovascular, active …

August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data

DC Poole, RN Pittman, TI Musch… - The Journal of …, 2020‏ - Wiley Online Library
August Krogh twice won the prestigious international Steegen Prize, for nitrogen metabolism
(1906) and overturning the concept of active transport of gases across the pulmonary …

Metabolic and performance‐related consequences of exercising at and slightly above MLSS

D Iannetta, EC Inglis, C Fullerton… - … journal of medicine …, 2018‏ - Wiley Online Library
Exercising at the maximal lactate steady state (MLSS) results in increased but stable
metabolic responses. We tested the hypothesis that even a slight increase above MLSS (10 …

Muscle oxygen saturation rates coincide with lactate-based exercise thresholds

PM Batterson, BS Kirby, G Hasselmann… - European journal of …, 2023‏ - Springer
Introduction Monitoring muscle metabolic activity via blood lactate is a useful tool for
understanding the physiological response to a given exercise intensity. Recent indications …

Limb blood flow and muscle oxygenation responses during handgrip exercise above vs. below critical force

SM Hammer, AM Alexander, KD Didier… - Microvascular …, 2020‏ - Elsevier
This study compared the brachial artery blood flow (Q̇ BA) and microvascular oxygen
delivery responses during handgrip exercise above vs. below critical force (CF; the isometric …

Muscle oxygen saturation breakpoints reflect ventilatory thresholds in both cycling and running

A Feldmann, L Ammann, F Gächter… - Journal of human …, 2022‏ - pmc.ncbi.nlm.nih.gov
Pulmonary gas exchange analysis was compared to changes in muscle oxygen saturation
as measured by near-infrared spectroscopy. First, ventilatory thresholds determined by …

Reactive hyperemia half-time response is associated with skeletal muscle oxygen saturation changes during cycling exercise

JR Dellinger, A Figueroa, JU Gonzales - Microvascular Research, 2023‏ - Elsevier
We investigated the relationship between muscle microvascular responses during reactive
hyperemia as assessed using near-infrared spectroscopy (NIRS) with changes in skeletal …

Relationship among muscle strength, muscle endurance, and skeletal muscle oxygenation dynamics during ramp incremental cycle exercise

S Nemoto, T Nakabo, N Tashiro, A Kishino… - Scientific Reports, 2024‏ - nature.com
Abstract Peak oxygen uptake (VO2), evaluated as exercise tolerance, is a strong predictor of
life prognosis regardless of health condition. Several previous studies have reported that …

Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction

DC Poole - Journal of Applied Physiology, 2019‏ - journals.physiology.org
This review strikes at the very heart of how the microcirculation functions to facilitate blood-
tissue oxygen, substrate, and metabolite fluxes in skeletal muscle. Contemporary evidence …

[HTML][HTML] Critical oxygenation: can muscle oxygenation inform us about critical power?

A Feldmann, D Erlacher - Medical hypotheses, 2021‏ - Elsevier
The power-duration relationship is well documented for athletic performance and is
formulated out mathematically in the critical power (CP) model. The CP model, when applied …