Gut reactions: breaking down xenobiotic–microbiome interactions

G Clarke, KV Sandhu, BT Griffin, TG Dinan… - Pharmacological …, 2019 - Elsevier
The microbiome plays a key role in health and disease, and there has been considerable
interest in therapeutic targeting of the microbiome as well as mining this rich resource in …

Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development

J Allen, CL Sears - Genome medicine, 2019 - Springer
In recent years, the number of studies investigating the impact of the gut microbiome in
colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes …

Current understanding of the gut microbiota sha** mechanisms

CS Chang, CY Kao - Journal of biomedical science, 2019 - Springer
Increasing evidences have shown strong associations between gut microbiota and many
human diseases, and understanding the dynamic crosstalks of host-microbe interaction in …

Eating microRNAs: pharmacological opportunities for cross‐kingdom regulation and implications in host gene and gut microbiota modulation

L del Pozo‐Acebo… - British Journal of …, 2021 - Wiley Online Library
Cross‐kingdom communication via non‐coding RNAs is a recent discovery. Exogenous
microRNAs (exog‐miRNAs) mainly enter the host via the diet. Generally considered …

The roles of the gut microbiota–miRNA interaction in the host pathophysiology

M Li, WD Chen, YD Wang - Molecular Medicine, 2020 - Springer
The gut microbiota regulates the biological processes of organisms acting like
'another'genome, affecting the health and disease of the host. MicroRNAs, as important …

New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics

G Dothel, MR Barbaro, A Di Vito, G Ravegnini… - Journal of …, 2023 - Springer
Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of
the gut–brain axis, intestinal permeability, mucosal neuro-immune interactions, and …

Crohn's disease recurrence updates: first surgery vs. surgical relapse patients display different profiles of ileal microbiota and systemic microbial-associated …

E Russo, L Cinci, L Di Gloria, S Baldi… - Frontiers in …, 2022 - frontiersin.org
Background and aims Crohn's disease (CD) pathogenesis is still unclear. Remodeling in
mucosal microbiota and systemic immunoregulation may represent an important component …

Probiotics and MicroRNA: their roles in the host–microbe interactions

Y Zhao, Y Zeng, D Zeng, H Wang, M Zhou… - Frontiers in …, 2021 - frontiersin.org
Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis–
the dynamic and healthy interactions between host and gut microorganisms. In addition …

Role of gut microbiota in epigenetic regulation of colorectal Cancer

Y Zhao, C Wang, A Goel - Biochimica et Biophysica Acta (BBA)-Reviews …, 2021 - Elsevier
Colorectal cancer (CRC) remains one of the most commonly diagnosed cancers and a
leading cause of cancer-related deaths worldwide. The stepwise accumulation of epigenetic …

Cell-to-cell communication by host-released extracellular vesicles in the gut: implications in health and disease

N Diaz-Garrido, C Cordero, Y Olivo-Martinez… - International Journal of …, 2021 - mdpi.com
Communication between cells is crucial to preserve body homeostasis and health. Tightly
controlled intercellular dialog is particularly relevant in the gut, where cells of the intestinal …