Pathogenic mechanisms of HIV disease
Human immunodeficiency virus (HIV) infection is generally characterized by inefficient viral
transmission; an acute phase of intense viral replication and dissemination to lymphoid …
transmission; an acute phase of intense viral replication and dissemination to lymphoid …
Redefining the viral reservoirs that prevent HIV-1 eradication
E Eisele, RF Siliciano - Immunity, 2012 - cell.com
This Perspective proposes definitions for key terms in the field of HIV-1 latency and
eradication. In the context of eradication, a reservoir is a cell type that allows persistence of …
eradication. In the context of eradication, a reservoir is a cell type that allows persistence of …
Systemic effects of inflammation on health during chronic HIV infection
Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …
eliminates the risk of AIDS-related complications but does not restore full health. HIV …
Coronavirus 2019 and people living with human immunodeficiency virus: outcomes for hospitalized patients in New York City
Background There are limited data regarding the clinical impact of coronavirus disease
2019 (COVID-19) on people living with human immunodeficiency virus (PLWH). In this …
2019 (COVID-19) on people living with human immunodeficiency virus (PLWH). In this …
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
K Allers, G Hütter, J Hofmann… - Blood, The Journal …, 2011 - ashpublications.org
HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …
Microbial translocation in HIV infection: causes, consequences and treatment opportunities
NG Sandler, DC Douek - Nature Reviews Microbiology, 2012 - nature.com
Systemic immune activation is increased in HIV-infected individuals, even in the setting of
virus suppression with antiretroviral therapy. Although numerous factors may contribute …
virus suppression with antiretroviral therapy. Although numerous factors may contribute …
Immune activation and HIV persistence: implications for curative approaches to HIV infection
NR Klatt, N Chomont, DC Douek… - Immunological …, 2013 - Wiley Online Library
Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …
replication with combination antiretroviral therapy, both HIV and chronic …
Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy
TW Chun, DC Nickle, JS Justement… - The Journal of …, 2008 - academic.oup.com
Human immunodeficiency virus (HIV) persists in peripheral blood mononuclear cells despite
sustained, undetectable plasma viremia resulting from long-term antiretroviral therapy …
sustained, undetectable plasma viremia resulting from long-term antiretroviral therapy …
[BOOK][B] Viruses, plagues, and history: past, present, and future
MBA Oldstone - 2020 - books.google.com
More people were killed by smallpox during the twentieth century--over 300 million--than by
all of the wars of that period combined. In 1918 and 1919, influenza virus claimed over 50 …
all of the wars of that period combined. In 1918 and 1919, influenza virus claimed over 50 …
Cardiovascular disease and thrombosis in HIV infection
HIV infection has transitioned from an acute, fatal disease to a chronic one managed by
antiretroviral therapy. Thus, the aging population of people living with HIV (PLWH) continues …
antiretroviral therapy. Thus, the aging population of people living with HIV (PLWH) continues …