Structure and function of the ependymal barrier and diseases associated with ependyma disruption

AJ Jiménez, MD Domínguez-Pinos, MM Guerra… - Tissue …, 2014 - Taylor & Francis
The neuroepithelium is a germinal epithelium containing progenitor cells that produce
almost all of the central nervous system cells, including the ependyma. The neuroepithelium …

Astrogliosis in CNS pathologies: is there a role for microglia?

D Zhang, X Hu, L Qian, JP O'Callaghan… - Molecular neurobiology, 2010 - Springer
Astrogliosis, a cellular reaction with specific structural and functional characteristics,
represents a remarkably homotypic response of astrocytes to all kinds of central nervous …

Pathophysiology of congenital and neonatal hydrocephalus

JP McAllister II - Seminars in Fetal and Neonatal Medicine, 2012 - Elsevier
The pathophysiology of congenital and neonatal hydrocephalus is not well understood
although the prognosis for patients with this disorder is far from optimal. A major obstacle to …

Astrocytes acquire morphological and functional characteristics of ependymal cells following disruption of ependyma in hydrocephalus

R Roales-Buján, P Páez, M Guerra, S Rodríguez… - Acta …, 2012 - Springer
Hydrocephalic hyh mutant mice undergo a programmed loss of the neuroepithelium/
ependyma followed by a reaction of periventricular astrocytes, which form a new cell layer …

Decorin prevents the development of juvenile communicating hydrocephalus

H Botfield, AM Gonzalez, O Abdullah, AD Skjolding… - Brain, 2013 - academic.oup.com
In post-haemorrhagic and other forms of communicating hydrocephalus, cerebrospinal fluid
flow and drainage is obstructed by subarachnoid fibrosis in which the potent fibrogenic …

The relationship between ventricular dilatation, neuropathological and neurobehavioural changes in hydrocephalic rats

FE Olopade, MT Shokunbi, AL Sirén - Fluids and Barriers of the CNS, 2012 - Springer
Background The motor and cognitive deficits observed in hydrocephalus are thought to be
due to axonal damage within the periventricular white matter. This study was carried out to …

[HTML][HTML] AQP4, astrogenesis, and hydrocephalus: a new neurological perspective

L Castañeyra-Ruiz, I González-Marrero… - International Journal of …, 2022 - mdpi.com
Aquaporin 4 (AQP4) is a cerebral glial marker that labels ependymal cells and astrocytes'
endfeet and is the main water channel responsible for the parenchymal fluid balance …

What we should know about the cellular and tissue response causing catheter obstruction in the treatment of hydrocephalus

CA Harris, JP McAllister - Neurosurgery, 2012 - journals.lww.com
The treatment of hydrocephalus by cerebrospinal fluid shunting is plagued by ventricular
catheter obstruction. Shunts can become obstructed by cells originating from tissue normal …

Unveiling the role of astrogliosis in Alzheimer's disease Pathology: Insights into mechanisms and therapeutic approaches

M Paidlewar, S Kumari, R Dhapola, P Sharma… - International …, 2024 - Elsevier
Alzheimer's disease (AD) is one of the most debilitating age-related disorders that affect
people globally. It impacts social and cognitive behavior of the individual and is …

[HTML][HTML] NADPH oxidase-derived H2O2 mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease

L Hou, X Zhou, C Zhang, K Wang, X Liu, Y Che, F Sun… - Redox Biology, 2017 - Elsevier
Astrogliosis has long been recognized in Parkinson's disease (PD), the most common
neurodegenerative movement disorder. However, the mechanisms of how astroglia become …