Which lipid nanoparticle (LNP) designs work? A simple kinetic model linking LNP chemical structure to in vivo delivery performance

EH Roh, MO Sullivan, TH Epps III - ACS Applied Materials & …, 2024 - ACS Publications
Although lipid nanoparticles (LNPs) are the predominant nanocarriers for short-interfering
RNA (siRNA) delivery, most therapies use nearly identical formulations that have taken 30 …

Activation energy and force fields during topological transitions of fluid lipid vesicles

M Bottacchiari, M Gallo, M Bussoletti… - Communications …, 2022 - nature.com
Topological transitions of fluid lipid membranes are fundamental processes for cell life. For
example, they are required for endo-and exocytosis or to enable neurotransmitters to cross …