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Regulation of SIRT1 and its roles in inflammation
Y Yang, Y Liu, Y Wang, Y Chao, J Zhang, Y Jia… - Frontiers in …, 2022 - frontiersin.org
The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …
[HTML][HTML] Cytokine storm—definition, causes, and implications
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
The role of neutrophil extracellular traps in acute lung injury
Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …
morbidity and mortality. Neutrophils play a key role in the development of different forms of …
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome
S Kang, T Tanaka, H Inoue, C Ono… - Proceedings of the …, 2020 - pnas.org
Cytokine release syndrome (CRS) is a life-threatening complication induced by systemic
inflammatory responses to infections, including bacteria and chimeric antigen receptor T cell …
inflammatory responses to infections, including bacteria and chimeric antigen receptor T cell …
The neutrophil life cycle
Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …
[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts
Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …
Innate immune responses to trauma
Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …
Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review
In some patients, the inflammatory‐immune response to surgical injury progresses to a
harmful, dysregulated state. We posit that postoperative systemic inflammatory dysregulation …
harmful, dysregulated state. We posit that postoperative systemic inflammatory dysregulation …
Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment
Y Yang, X Zhao, J Yu, X Chen, R Wang… - Bioactive …, 2021 - pmc.ncbi.nlm.nih.gov
The treatment of diabetic chronic wounds remains a global challenge due to the up-
regulated inflammation response, oxidant stress, and persistent infection during healing …
regulated inflammation response, oxidant stress, and persistent infection during healing …