Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …

Multiplexed modulation of endogenous genes is crucial for sophisticated gene therapy and
cell engineering. CRISPR–Cas12a systems enable versatile multiple-genomic-loci targeting …

Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is
particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays …

Myc is one of the most well-known oncogenes driving tumorigenesis in a wide variety of
tissues. From the brain to blood, its deregulation derails physiological pathways that grant …

Progressive and irreversible vision loss in mature and aging adults creates a health and
economic burden, worldwide. Despite the advancements of many contemporary therapies to …

Retinal ganglion cells (RGCs) are the only projection neurons in the neural retina. They
receive and integrate visual signals from upstream retinal neurons in the visual circuitry and …

Glaucoma, the second leading cause of blindness worldwide, is an incurable
neurodegenerative disorder due to the dysfunction of retinal ganglion cells (RGCs). RGCs …

Transcription factor aryl hydrocarbon receptor (AHR) has emerged as one of the main
regulators involved both in different homeostatic cell functions and tumor progression. Being …

Background In addition to rescuing injured retinal ganglion cells (RGCs) by stimulating the
intrinsic growth ability of damaged RGCs in various retinal/optic neuropathies, increasing …

Retinal ganglion cells (RGCs) are the projection neurons of the retina, and their death
promotes an irreversible blindness. Several factors were described to control their genesis …