Protein biopharmaceuticals are macromolecules with a therapeutic effect, commonly
produced by the recombinant DNA technology. They have emerged as important …

Fc‐Fusion proteins represent a successful class of biopharmaceutical products, with already
13 drugs approved in the European Union and United States as well as three biosimilar …

Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses
since 2014. The method provides high resolution capable of separating carbohydrates by …

Capillary electrophoresis (CE) played an important role in developments in the life sciences.
The technique is nowadays used for the analysis of both large and small molecules in …

We report a new online capillary isoelectric focusing-mass spectrometry (CIEF-MS) method
for monoclonal antibody (mAb) charge variant analysis using an electrokinetically pumped …

Charge sensitive separation methods such as ion exchange chromatography (CEX) and
capillary electrophoresis (CE) have recently been coupled to mass spectrometry to facilitate …

Biopharmaceuticals are one of the fastest-growing sectors in the biotechnology industry.
Within the umbrella of biopharmaceuticals, the biosimilar segment is expanding with …

Accelerated development of new therapeutics in an increasingly competitive landscape
requires the use of high throughput analytical platforms. In addition, the complexity of novel …

Owing to rapid growth in the elucidation of genome sequences of various organisms,
deducing proteome sequences has become imperative, in order to have an improved …

The N-glycans attached to the Fab and Fc domains play distinct roles in modulating the
functions of antibodies. However, posttranslational site-selective modifications of glycans in …