The physical microenvironment of cancer is characterized by elevated stiffness and tissue
pressure, the main component of which is the interstitial fluid pressure (IFP). Elevated IFP is …

Our understanding of tumour biology has evolved over the past decades and cancer is now
viewed as a complex ecosystem with interactions between various cellular and non-cellular …

The development of blood vessels, referred to as angiogenesis, is an intricate process
regulated spatially and temporally through a delicate balance between the qualitative and …

Advanced in vitro systems such as multicellular spheroids and lab‐on‐a‐chip devices have
been developed, but often fall short in reproducing the tissue scale and self‐organization of …

Understanding the uptake of a drug by diseased tissue, and the drug's subsequent
spatiotemporal distribution, are central factors in the development of effective targeted …

Cerebrospinal fluid (CSF) in the paravascular spaces of the surface arteries (sPVS) is a vital
pathway in brain waste clearance. Arterial pulsations may be the driving force of the …

Radiotherapy is commonly used to treat cancer, and localized energy deposited by
radiotherapy has the potential to chemically uncage prodrugs; however, it has been …

Chemotherapy has an essential role not only in advanced solid tumor therapy intervention
but also in society's health at large. Chemoresistance, however, seriously restricts the …

Increased stiffness in the extracellular matrix (ECM) contributes to tumor progression and
metastasis. Therefore, stromal modulating therapies and accompanying biomarkers are …

We characterized the in vivo interstitial fluid (IF) content of extracellular vesicles (EVs) using
the GFP‐4T1 syngeneic murine cancer model to study EVs in‐transit to the draining lymph …