Neuroimaging standards for research into small vessel disease—advances since 2013

M Duering, GJ Biessels, A Brodtmann, C Chen… - The Lancet …, 2023 - thelancet.com
Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …

Small vessel disease: mechanisms and clinical implications

JM Wardlaw, C Smith, M Dichgans - The Lancet Neurology, 2019 - thelancet.com
Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical …

What are white matter hyperintensities made of? Relevance to vascular cognitive impairment

JM Wardlaw, MC Valdés Hernández… - Journal of the …, 2015 - ahajournals.org
White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

[HTML][HTML] Stroke injury, cognitive impairment and vascular dementia

RN Kalaria, R Akinyemi, M Ihara - … Acta (BBA)-Molecular Basis of Disease, 2016 - Elsevier
The global burden of ischaemic strokes is almost 4-fold greater than haemorrhagic strokes.
Current evidence suggests that 25–30% of ischaemic stroke survivors develop immediate or …

Update on cerebral small vessel disease: a dynamic whole-brain disease

Y Shi, JM Wardlaw - Stroke and vascular neurology, 2016 - svn.bmj.com
Cerebral small vessel disease (CSVD) is a very common neurological disease in older
people. It causes stroke and dementia, mood disturbance and gait problems. Since it is …

The pathology and pathophysiology of vascular dementia

RN Kalaria - Neuropharmacology, 2018 - Elsevier
Vascular dementia (VaD) is widely recognised as the second most common type of
dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide …

The potential impact of neuroimaging and translational research on the clinical management of lacunar stroke

S Rudilosso, A Rodríguez-Vázquez, X Urra… - International journal of …, 2022 - mdpi.com
Lacunar infarcts represent one of the most frequent subtypes of ischemic strokes and may
represent the first recognizable manifestation of a progressive disease of the small …

The overlap between vascular disease and Alzheimer's disease-lessons from pathology

J Attems, KA Jellinger - BMC medicine, 2014 - Springer
Recent epidemiological and clinico-pathological data indicate considerable overlap
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …

A novel imaging marker for small vessel disease based on skeletonization of white matter tracts and diffusion histograms

E Baykara, B Gesierich, R Adam… - Annals of …, 2016 - Wiley Online Library
Objective To establish a fully automated, robust imaging marker for cerebral small vessel
disease (SVD) and related cognitive impairment that is easy to implement, reflects disease …

Advances in understanding the pathophysiology of lacunar stroke: a review

RW Regenhardt, AS Das, EH Lo, LR Caplan - JAMA neurology, 2018 - jamanetwork.com
Importance Stroke is the second leading cause of death in the world, and nearly one-third of
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …