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Isoniazid derivatives and their anti-tubercular activity
Tuberculosis (TB), which has been a scourge of humanity for thousands of years, is a
worldwide pandemic disease caused mainly by Mycobacterium tuberculosis (MTB). The …
worldwide pandemic disease caused mainly by Mycobacterium tuberculosis (MTB). The …
Isatin derivatives as broad-spectrum antiviral agents: the current landscape
In recent decades, several viruses have resulted in large outbreaks with serious health,
economic and social consequences. The current unprecedented outbreak of the new …
economic and social consequences. The current unprecedented outbreak of the new …
Benzofuran derivatives and their anti-tubercular, anti-bacterial activities
Benzofuran is a fundamental structural unit in a variety of biologically active natural
products, and its derivatives display various biological properties. Some benzofuran …
products, and its derivatives display various biological properties. Some benzofuran …
Fluoroquinolone-isatin hybrids and their biological activities
Z Xu, SJ Zhao, ZS Lv, F Gao, Y Wang, F Zhang… - European Journal of …, 2019 - Elsevier
Hybridization of different pharmacophores from various bioactive substances into a single
molecule is the potential weapon to prevent the drug resistance since this strategy can …
molecule is the potential weapon to prevent the drug resistance since this strategy can …
Structure-based discovery of substituted 4, 5′-bithiazoles as novel DNA gyrase inhibitors
Bacterial DNA gyrase is a well-established and validated target for the development of novel
antibacterials. Starting from the available structural information about the binding of the …
antibacterials. Starting from the available structural information about the binding of the …
Synthesis and antibacterial activity of Schiff bases of 5-substituted isatins
Based on the existing reports on the bioactive isatin derivatives, a number of Schiff bases
were synthesized by reacting 5-substituted isatins with bioactive amines/hydrazides and …
were synthesized by reacting 5-substituted isatins with bioactive amines/hydrazides and …
Indole derivatives as anti-tubercular agents: An overview on their synthesis and biological activities
Background: The indole framework is considered as one of the privileged structures in the
area of medicinal chemistry and drug discovery because compounds containing this …
area of medicinal chemistry and drug discovery because compounds containing this …
Synthesis, characterization, DFT analysis, biological evaluation, and molecular docking of Schiff Base derived from Isatin–isoniazid and its metal (II) complexes
A series of octahedral Zn (II), Cu (II), Ni (II), and Co (II) complexes have been synthesized
with ONO donor Schiff base ligand N'-(6-chloro-2-oxoindolin-3-ylidene) nicotinohydrazide …
with ONO donor Schiff base ligand N'-(6-chloro-2-oxoindolin-3-ylidene) nicotinohydrazide …
Isatin derivatives with potential antitubercular activities
D Jiang, GQ Wang, X Liu, Z Zhang… - Journal of …, 2018 - Wiley Online Library
Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …
Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives
YX Dong, LX Gao, Q Cao, ZT Cao, SY Gan… - The Journal of …, 2024 - ACS Publications
The isatin group is widespread in nature and is considered to be a privileged building block
for drug discovery. In order to develop novel SHP1 inhibitors with fluorescent properties as …
for drug discovery. In order to develop novel SHP1 inhibitors with fluorescent properties as …