Tremor in Parkinson's disease has several mysterious features. Clinically, tremor is seen in
only three out of four patients with Parkinson's disease, and tremor-dominant patients …

Tremor is one of the primary motor symptoms of Parkinson's disease (PD), and it is
characterized by a highly phenomenological heterogeneity. Clinical and experimental …

Deep brain stimulation (DBS) is increasingly applied for the treatment of brain disorders, but
its mechanism of action remains unknown. Here we evaluate the effect of basal ganglia DBS …

Hyperkinetic states are common in human movement disorders, but their neural basis
remains uncertain. One such condition is dyskinesia, a serious adverse effect of medical and …

An important mechanism for large-scale interactions between cortical areas involves
coupling between the phase and the amplitude of different brain rhythms. Could basal …

Oscillations form a ubiquitous feature of the central nervous system. Evidence is accruing
from cortical and sub-cortical recordings that these rhythms may be functionally important …

Oscillations in neural activity play a critical role in neural computation and communication.
There is intriguing new evidence that the nonsinusoidal features of the oscillatory waveforms …

Feedback control of deep brain stimulation (DBS) in Parkinson's disease has great potential
to improve efficacy, reduce side effects, and decrease the cost of treatment. In this, the timing …

The significance of oscillations that characterize the subthalamic nucleus in Parkinson's
disease is still under debate. Here, we analysed the spectral and spatial characteristics of …

Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia)
have a long history and primarily model the consequences of dopamine loss in the basal …