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Nanotechnology applications for improved delivery of antiretroviral drugs to the brain
Human immunodeficiency virus (HIV) can gain access to the central nervous system during
the early course of primary infection. Once in the brain compartment the virus actively …
the early course of primary infection. Once in the brain compartment the virus actively …
In vitro and ex vivo models to study drug delivery barriers in the posterior segment of the eye
Many ocular disorders leading to blindness could benefit from efficient delivery of
therapeutics to the retina. However, despite extensive research into drug delivery vehicles …
therapeutics to the retina. However, despite extensive research into drug delivery vehicles …
Glioma-targeted dual functionalized thermosensitive Ferri-liposomes for drug delivery through an in vitro blood–brain barrier
To date, the delivery of therapeutic agents for malignant brain tumors (such as glioblastoma
multiforme (GBM)) remains a significant obstacle due to the existence of the blood–brain …
multiforme (GBM)) remains a significant obstacle due to the existence of the blood–brain …
Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure
The outer blood–retinal barrier (oBRB) tightly controls the transport processes between the
neural tissue of the retina and the underlying blood vessel network. The barrier is formed by …
neural tissue of the retina and the underlying blood vessel network. The barrier is formed by …
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration
The retinal pigment epithelium (RPE)-choriocapillaris (CC) complex in the eye is
compromised in age-related macular degeneration (AMD) and related macular dystrophies …
compromised in age-related macular degeneration (AMD) and related macular dystrophies …
Cellular regeneration strategies for macular degeneration: past, present and future
Despite considerable effort and significant therapeutic advances, age-related macular
degeneration (AMD) remains the commonest cause of blindness in the developed world …
degeneration (AMD) remains the commonest cause of blindness in the developed world …
Acute and continuous exposure of airborne fine particulate matter (PM2.5): diverse outer blood–retinal barrier damages and disease susceptibilities
Y Gu, F Sheng, M Gao, L Zhang, S Hao, S Chen… - Particle and Fibre …, 2023 - Springer
Background The association between air pollution and retinal diseases such as age-related
macular degeneration (AMD) has been demonstrated, but the pathogenic correlation is …
macular degeneration (AMD) has been demonstrated, but the pathogenic correlation is …
The essential role of the choriocapillaris in vision: novel insights from imaging and molecular biology
The choriocapillaris, a dense capillary network located at the posterior pole of the eye, is
essential for supporting normal vision, supplying nutrients, and removing waste products …
essential for supporting normal vision, supplying nutrients, and removing waste products …
Sorsby fundus dystrophy–a review of pathology and disease mechanisms
Sorsby fundus dystrophy (SFD) is an autosomal dominant macular dystrophy with an
estimated prevalence of 1 in 220,000 and an onset of disease around the 4th to 6th decade …
estimated prevalence of 1 in 220,000 and an onset of disease around the 4th to 6th decade …
Organ-on-a-chip technologies for advanced blood–retinal barrier models
The blood–retinal barrier (BRB) protects the retina by maintaining an adequate
microenvironment for neuronal function. Alterations of the junctional complex of the BRB and …
microenvironment for neuronal function. Alterations of the junctional complex of the BRB and …