Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-
regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid …

Background Cognitive impairment, an increasing mental health issue, is a core feature of the
aging brain and neurodegenerative diseases. Industrialized nations especially, have …

Alzheimer disease (AD) is the most common neurodegenerative disease. An imbalance
between the production and clearance of Aβ (amyloid beta) is considered to be actively …

Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, eg
the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular …

Alzheimer's disease (AD) is characterized by progressive neurodegeneration in the cerebral
cortex, histopathologically hallmarked by amyloid β (Aβ) extracellular plaques and …

Astrocytes regulate synaptic communication and are essential for proper brain functioning.
In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an …

Wnt signaling function starts during the development of the nervous system and is crucial for
synaptic plasticity in the adult brain. Clearly Wnt effects in synaptic and plastic processes are …

The nuclear liver X receptors (LXRα/β) and peroxisome proliferator-activated receptors
(PPARα/γ) are involved in the regulation of multiple biological processes, including lipid …

Numerous studies suggest energy failure and accumulative intracellular waste play a causal
role in the pathogenesis of several neurodegenerative disorders and Alzheimer's disease …