Antibiotic resistance is a major health concern globally and has been estimated to cause 10
million deaths worldwide by year 2050 if the current trend of inappropriate and excessive …

The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

In the face of diminishing therapeutic options for the treatment of infections caused by
multidrug-resistant, Gram-negative bacteria, clinicians are increasingly using colistin and …

Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to
establish rational dosage regimens of antimicrobial agents in human and veterinary …

Purpose An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD)
principles that determine response to antimicrobial therapy can provide the clinician with …

Abstract Machine learning (ML) approaches have been widely adopted within the early
stages of the drug discovery process, particularly within the context of small-molecule drug …

Within a few years after the first successful clinical use of penicillin, investigations were
conducted in animal infection models to explore a range of factors that were considered …

Antibiotics are the current standard-of-care treatment for uncomplicated urinary tract
infections (uUTIs). However, increasing rates of bacterial antibiotic resistance necessitate …

Animal infection models in the pharmacokinetic/pharmacodynamic (PK/PD) evaluation of
antimicrobial therapy serve an important role in preclinical assessments of new antibiotics …

Objectives This systematic review focuses on the use of the in vitro hollow fibre infection
model (HFIM) for microbial culture. We summarize the direction of the field to date and …