The neural basis of psychedelic action
Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …
perception, cognition and mood. In this review, we focus on the basic neurobiology …
REBUS and the anarchic brain: toward a unified model of the brain action of psychedelics
This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …
[HTML][HTML] Single-dose psilocybin for a treatment-resistant episode of major depression
Background Psilocybin is being studied for use in treatment-resistant depression. Methods
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …
Trial of psilocybin versus escitalopram for depression
R Carhart-Harris, B Giribaldi, R Watts… - … England Journal of …, 2021 - Mass Medical Soc
Background Psilocybin may have antidepressant properties, but direct comparisons
between psilocybin and established treatments for depression are lacking. Methods In a …
between psilocybin and established treatments for depression are lacking. Methods In a …
Single-dose psilocybin treatment for major depressive disorder: a randomized clinical trial
Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …
Percentage of heavy drinking days following psilocybin-assisted psychotherapy vs placebo in the treatment of adult patients with alcohol use disorder: a randomized …
Importance Although classic psychedelic medications have shown promise in the treatment
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …
Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial
Importance Major depressive disorder (MDD) is a substantial public health burden, but
current treatments have limited effectiveness and adherence. Recent evidence suggests that …
current treatments have limited effectiveness and adherence. Recent evidence suggests that …
Psilocybin desynchronizes the human brain
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …
Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up
Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …
substantial and rapid antidepressant effects in patients with major depressive disorder …
Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …
warrants a better understanding of the neurobiological mechanisms underlying the effects of …