Uncontrolled regulation of specific metalloenzymes plays important roles in several
diseases like tumor metastasis and inflammation. Therefore, selective metalloenzyme …

A series of novel aliphatic sulfonamide derivatives (1–7) were synthesized and
characterized by elemental analyses, FT-IR, 1H NMR, 13C NMR and LC–MS techniques. All …

The discovery of acetylcholinesterase inhibitors is important for the treatment of Alzheimer's
disease (AD), known as the most common type of dementia. Due to the side effects of …

Sulfonamide hydroxamates were designed and synthesized as efficient matrix
metalloproteinase (MMP) inhibitors since the discovery of CGS 27023A in 1994. The …

Eight new hybrid constructs containing a series of sulfonamide and 1, 2, 3-triazole units
were designed and synthesized. Anticancer, antioxidant and cholinesterase activities of …

BACKGROUND: The quality of platelet concentrates (PCs) is primarily determined in vitro by
selective methods (eg, pH, aggregometry), which provide only limited information on certain …

To better understand the role of dopamine D4 receptor (D4R) in glioblastoma (GBM), in the
present paper, new ligands endowed with high affinity and selectivity for D4R were …

We recently described the synthesis and characterization of a novel
difluorinatedbenzylidene analog of curcumin, commonly referred as CDF, which …

A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by
nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by …

Inhibition of the matrix metalloproteinases (MMPs) is effective against metastasis of
secondary tumours. Previous MMP inhibitors have failed in clinical trials due to their off …