[HTML][HTML] Bacterial biofilm eradication agents: a current review

AD Verderosa, M Totsika, KE Fairfull-Smith - Frontiers in chemistry, 2019 - frontiersin.org
Most free-living bacteria can attach to surfaces and aggregate to grow into multicellular
communities encased in extracellular polymeric substances called biofilms. Biofilms are …

The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic

A Shariati, M Arshadi, MA Khosrojerdi… - Frontiers in public …, 2022 - frontiersin.org
For around three decades, the fluoroquinolone (FQ) antibiotic ciprofloxacin has been used
to treat a range of diseases, including chronic otorrhea, endocarditis, lower respiratory tract …

Ciprofloxacin derivatives and their antibacterial activities

GF Zhang, X Liu, S Zhang, B Pan, ML Liu - European journal of medicinal …, 2018 - Elsevier
Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …

Combination therapies for biofilm inhibition and eradication: a comparative review of laboratory and preclinical studies

S Hawas, AD Verderosa, M Totsika - Frontiers in cellular and infection …, 2022 - frontiersin.org
Microbial biofilms are becoming increasingly difficult to treat in the medical setting due to
their intrinsic resistance to antibiotics. To combat this, several biofilm dispersal agents are …

Fluoroquinolones hybrid molecules as promising antibacterial agents in the fight against antibacterial resistance

IA Lungu, OL Moldovan, V Biriș, A Rusu - Pharmaceutics, 2022 - mdpi.com
The emergence of bacterial resistance has motivated researchers to discover new
antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential …

Nitroxide radical polymers–a versatile material class for high-tech applications

KA Hansen, JP Blinco - Polymer Chemistry, 2018 - pubs.rsc.org
Nitroxides are a versatile class of stable free radicals that have long established themselves
in a wide range of applications. Their incorporation into macromolecular architectures has …

Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules

J Fedorowicz, J Sączewski - Monatshefte für Chemie-Chemical Monthly, 2018 - Springer
This review is aimed to provide extensive survey of quinolones and fluoroquinolones for a
variety of applications ranging from metal complexes and nanoparticle development to …

Simple and Efficient Synthesis of 3-Aryl-2-oxazolidinone Scaffolds Enabling Increased Potency toward Biofilms

ARN Ndukwe, S Hawas, J Qin… - Molecular …, 2023 - ACS Publications
Infectious diseases caused by bacterial pathogens are a leading cause of mortality
worldwide. In particular, recalcitrant bacterial communities known as biofilms are implicated …

Isothiazolone–Nitroxide Hybrids with Activity against Antibiotic-Resistant Staphylococcus aureus Biofilms

AD Verderosa, S Hawas, J Harris, M Totsika… - ACS …, 2022 - ACS Publications
Isothiazolones are widely used as biocides in industrial processing systems and personal
care products, but their use to treat infections in humans has been hampered by their …

Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity

A Qian, Y Zheng, R Wang, J Wei, Y Cui, X Cao… - Bioorganic & Medicinal …, 2018 - Elsevier
In this letter, we report our efforts to design, synthesize and evaluate biological activities of a
series of novel hybridized compounds containing 1-tetrazole and 4-pyridinyl-1, 2, 4-triazole …