Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Malignant transformation can result in melanoma cells that resemble different stages of their
embryonic development. Our gene expression analysis of human melanoma cell lines and …

Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

Immunotherapy and particularly immune checkpoint inhibitors have resulted in remarkable
clinical responses in patients with immunogenic tumors, although most cancers develop …

Transcriptional reprogramming of proliferative melanoma cells into a phenotypically distinct
invasive cell subpopulation is a critical event at the origin of metastatic spreading. Here we …

Melanocyte development provides an excellent model for studying more complex
developmental processes. Melanocytes have an apparently simple aetiology, differentiating …

The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

Increased activity of the epigenetic modifier EZH2 has been associated with different
cancers. However, evidence for a functional role of EZH2 in tumorigenesis in vivo remains …

INTRODUCTION The “cancerized field” concept posits that cells in a given tissue sharing an
oncogenic mutation are cancer-prone, yet only discreet clones within the field initiate tumors …