The restriction factors of human immunodeficiency virus
Cellular proteins called" restriction factors" can serve as powerful blockades to HIV
replication, but the virus possesses elaborate strategies to circumvent these barriers. First …
replication, but the virus possesses elaborate strategies to circumvent these barriers. First …
Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms
Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …
that, broadly speaking, seeks to understand how changes in development drive major …
Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal
One of the major virulence factors of SARS-CoV-2, NSP1, is a vital drug target due to its role
in host immune evasion through multiple pathways. NSP1 protein is associated with …
in host immune evasion through multiple pathways. NSP1 protein is associated with …
Cell-surface glycosaminoglycans regulate the cellular uptake of charged polystyrene nanoparticles
Engineered nanoparticles approaching the cell body will first encounter and interact with cell-
surface glycosaminoglycans (GAGs) before reaching the plasma membrane and becoming …
surface glycosaminoglycans (GAGs) before reaching the plasma membrane and becoming …
Molecular biomarkers, network biomarkers, and dynamic network biomarkers for diagnosis and prediction of rare diseases
S Tang, K Yuan, L Chen - Fundamental Research, 2022 - Elsevier
The difficulty of converting scientific research findings into novel pharmacological treatments
for rare and life-threatening diseases is enormous. Biomarkers related to multiple biological …
for rare and life-threatening diseases is enormous. Biomarkers related to multiple biological …
Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling
R Hatori, BM Wood, G Oliveira Barbosa, TB Kornberg - Elife, 2021 - elifesciences.org
Morphogen signaling proteins disperse across tissues to activate signal transduction in
target cells. We investigated dispersion of Hedgehog (Hh), Wnt homolog Wingless (Wg), and …
target cells. We investigated dispersion of Hedgehog (Hh), Wnt homolog Wingless (Wg), and …
Exploring gene regulation and biological processes in insects: Insights from omics data using gene regulatory network models
Gene regulatory network (GRN) comprises complicated yet intertwined gene-regulator
relationships. Understanding the GRN dynamics will unravel the complexity behind the …
relationships. Understanding the GRN dynamics will unravel the complexity behind the …
[HTML][HTML] Reconstructing gene regulatory networks in single-cell transcriptomic data analysis
H Dai, QQ **, L Li, LN Chen - Zoological research, 2020 - ncbi.nlm.nih.gov
Gene regulatory networks play pivotal roles in our understanding of biological processes/
mechanisms at the molecular level. Many studies have developed sample-specific or cell …
mechanisms at the molecular level. Many studies have developed sample-specific or cell …
Design, synthesis, and biological evaluation of 1,4,7,8‐tetrahydro‐5H‐furo[3,4‐b]pyrazolo[4,3‐e]pyridin‐5‐one‐based azo dyes
SF Kamaloddin‐Ezabadi, NO Mahmoodi… - Journal of …, 2023 - Wiley Online Library
Abstract Some 1, 4, 7, 8‐tetrahydro‐5 H‐furo [3, 4‐b] pyrazolo [4, 3‐e] pyridin‐5‐ones
containing azo group were synthesized by a three‐component one‐pot reaction of a …
containing azo group were synthesized by a three‐component one‐pot reaction of a …
Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila
G Pierini, C Dahmann - Scientific Reports, 2023 - nature.com
During tissue development, gradients of secreted signaling molecules known as
morphogens provide cells with positional information. The mechanisms underlying …
morphogens provide cells with positional information. The mechanisms underlying …