Corticogenesis is an intricate process controlled temporally and spatially by many intrinsic
and extrinsic factors. Alterations during this important process can lead to severe cortical …

Malformations of human cortical development (MCD) can cause severe disabilities. The lack
of human‐specific models hampers our understanding of the molecular underpinnings of the …

Subcortical heterotopia is a cortical malformation associated with epilepsy, intellectual
disability, and an excessive number of cortical neurons in the white matter. Echinoderm …

The rate of discovery and increased understanding of genetic causes for
neurodevelopmental disorders has peaked over the past decade. It is well recognised that …

Grey matter heterotopia (GMH) are neurodevelopmental disorders associated with abnormal
cortical function and epilepsy. Subcortical band heterotopia (SBH) and periventricular …

Congenital neurodevelopmental anomalies are present from birth and are characterized by
an abnormal development of one or more structures of the brain. Brain structural anomalies …

The cerebral cortex is a structure that underlies various brain functions, including cognition
and language. Mammalian cerebral cortex starts develo** during the embryonic period …

EML1 encodes the protein Echinoderm microtubule‐associated protein‐like 1 or EMAP‐1
that binds to the microtubule complex. Mutations in this gene resulting in complex brain …

Completion of the first meiosis is an essential prerequisite for producing a functionally
normal egg for fertilization and embryogenesis, but the precise mechanisms governing …

Mutations in cytoskeletal proteins can cause early infantile and childhood epilepsies by
misplacing newly born neurons and altering neuronal connectivity. In the adult epileptic …