Rosmarinic acid–human pharmacokinetics and health benefits

M Hitl, N Kladar, N Gavarić, B Božin - Planta medica, 2021 - thieme-connect.com
Rosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae)
plant species. It is considered responsible for a wide spectrum of biological and …

Structure‐based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases

S Anwar, S Khan, A Shamsi, F Anjum… - Journal of cellular …, 2021 - Wiley Online Library
MAP/microtubule affinity‐regulating kinase 4 (MARK4) is a member of serine/threonine
kinase family and considered an attractive drug target for many diseases. Screening of …

Comprehensive insight into the molecular interaction of rutin with human transferrin: Implication of natural compounds in neurodegenerative diseases

A Shamsi, M Furkan, RH Khan, MS Khan… - International Journal of …, 2023 - Elsevier
Neurodegeneration, a process of irreversible neuronal damage, is characterized by a
damaged neuronal structure and function. The interplay between various proteins maintains …

Inhibiting CDK6 activity by quercetin is an attractive strategy for cancer therapy

M Yousuf, P Khan, A Shamsi, M Shahbaaz… - ACS …, 2020 - ACS Publications
Cyclin-dependent kinase 6 (CDK6) is a potential drug target that plays an important role in
the progression of different types of cancers. We performed in silico and in vitro screening of …

Therapeutic plasma exchange with albumin: a new approach to treat Alzheimer's disease

M Boada, P Martínez-Lage… - Expert Review of …, 2021 - Taylor & Francis
Introduction Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most
common cause of dementia. It has a complex pathophysiology that is not yet completely …

Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4

S Anwar, S Khan, F Anjum, A Shamsi… - Journal of cellular …, 2022 - Wiley Online Library
Identifying novel molecules as potential kinase inhibitors are gaining significant attention
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …

Investigating MARK4 inhibitory potential of Bacopaside II: targeting Alzheimer's disease

S Anwar, T Mohammad, MK Azhar, H Fatima… - International journal of …, 2023 - Elsevier
Microtubule affinity regulating kinase 4 (MARK4) is known to hyperphosphorylate tau
protein, which subsequently causes Alzheimer's disease (AD). MARK4 is a well-validated …

Interaction of a cobalt (III) complex containing β-amino alcohol with human serum albumin (HSA): spectroscopic and molecular docking methods

N Shahabadi, S Hadidi, Z Abdoli, Z Mardani - Journal of Molecular Liquids, 2023 - Elsevier
The current work aimed to explore the binding interaction of cobalt (III) complex containing [2-
[(E)-({2-[(2-hydroxy ethyl) amino] ethyl} imino) methyl] phenol] ligand with human serum …

Binding divergence of polystyrene nanoparticles with serum albumin caused by surface functionalization

J Lan, Y Wang, H Li, R Guan, Z Zhao, Y Bao… - Science of The Total …, 2023 - Elsevier
Using a combination of spectroscopy, we devised an integrated structural strategy to
comprehensively profile the molecular details of the impact of differently functionalized …