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Microglia in neuroinflammation and neurodegeneration: from understanding to therapy
Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
The lung microbiome regulates brain autoimmunity
L Hosang, RC Canals, FJ van der Flier, J Hollensteiner… - Nature, 2022 - nature.com
Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated
autoimmune disease of the central nervous system. In addition, the lung serves as a niche …
autoimmune disease of the central nervous system. In addition, the lung serves as a niche …
Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities
G Wang, K Zhong, Z Wang, Z Zhang, X Tang… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults.
Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and …
Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and …
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
The role of glial cells in multiple sclerosis disease progression
Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …
sclerosis (MS), limited progress has been made in addressing primary progressive or …
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are
associated with late-onset Alzheimer's disease (AD). We demonstrate that amyloid plaque …
associated with late-onset Alzheimer's disease (AD). We demonstrate that amyloid plaque …
Immune cell regulation of glia during CNS injury and disease
Glial cells are abundant in the CNS and are essential for brain development and
homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a …
homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a …
Microglia-astrocyte crosstalk: an intimate molecular conversation
Microglia-astrocyte crosstalk has recently been at the forefront of glial research. Emerging
evidence illustrates that microglia-and astrocyte-derived signals are the functional …
evidence illustrates that microglia-and astrocyte-derived signals are the functional …