Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

Fundamental biological processes are carried out by curved epithelial sheets that enclose a
pressurized lumen. How these sheets develop and withstand three-dimensional …

Basic human functions such as breathing and digestion require mechanical stretching of
cells and tissues. However, when it comes to laboratory experiments, the mechanical …

Blebs and pseudopods can both power cell migration, with blebs often favored in tissues,
where cells encounter increased mechanical resistance. To investigate how migrating cells …

Model organisms have been key to understanding many core biological processes.
Dictyostelium amoebae have the attributes required to perform this role for chemotaxis, and …

Leukocyte transendothelial migration is crucial for innate immunity and inflammation. Upon
tissue damage or infection, leukocytes exit blood vessels by adhering to and probing …

Cellular forces are crucial for many biological processes but current methods to image them
have limitations with respect to data analysis, resolution and throughput. Here, we present a …

During metastasis, cancer cells navigate through a spatially heterogeneous extracellular
matrix (ECM). Physical properties of ECM, including the degree of confinement, influence …

Many biological processes involve the collective generation and transmission of mechanical
stresses across cell monolayers. In these processes, the monolayer undergoes lateral …