Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …

A decline in energy is common in aging, and the restoration of mitochondrial bioenergetics
may offer a common approach for the treatment of numerous age‐associated diseases …

Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …

The concept of 'successful aging'has long intrigued the scientific community. Despite this
long-standing interest, a consensus definition has proven to be a difficult task, due to the …

Vital osteocytes have been well known to function as an important orchestrator in the
preservation of robustness and fidelity of the bone remodeling process. Nevertheless, some …

Under normal physiological conditions, reactive oxygen species (ROS) serve as 'redox
messengers' in the regulation of intracellular signalling, whereas excess ROS may induce …

Muscle loss during aging and disuse is a highly prevalent and disabling condition, but
knowledge about cellular pathways mediating muscle atrophy is still limited. Given the …

Oxidative stress has been implicated in the etiology of age-related muscle loss (sarcopenia).
However, the underlying mechanisms by which oxidative stress contributes to sarcopenia …

Silent information regulators are potent NAD+-dependent protein deacetylases, which have
been shown to regulate gene silencing, muscle differentiation and DNA damage repair …

Caloric restriction (CR) without malnutrition slows the aging process and extends lifespan in
diverse species by unknown mechanisms. The inverse linear relationship between calorie …