Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related
somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations …

Loss of function TET2 mutation (TET2 MT) is one of the most frequently observed lesions in
clonal haematopoiesis (CH). TET2 a member TET-dioxygenase family of enzyme that along …

Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …

Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms
underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential …

With advances in sequencing, individuals with clonal hematopoiesis of indeterminate
potential (CHIP) are increasingly being identified, making it essential to understand its …

Chronic kidney disease (CKD) was responsible for 1.2 million deaths globally in 2016.
Despite the large and growing burden of CKD, treatment options are limited and generally …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related
phenomenon in which hematopoietic stem cells acquire mutations in a select set of genes …

The increased sensitivity of novel DNA sequencing techniques has made it possible to
identify somatic mutations in small circulating clones of haematopoietic stem cells. When the …

Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a
sizeable proportion of an individual's circulating blood cells are derived from a single …