Autoimmunity plays a significant role in the pathogenesis of demyelination. Multiple
sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and myelin …

The ability of B cells to generate antibodies and provide long-lived protective immunity is the
cornerstone of vaccination and has contributed to the success of modern medicine. The nine …

As the size and complexity of high‐dimensional (HD) cytometry data continue to expand,
comprehensive, scalable, and methodical computational analysis approaches are essential …

Altered composition of gut bacteria and changes to the production of their bioactive
metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of …

Cells of the skin and circulation are in constant two-way communication. Following exposure
of humans to sunlight or to phototherapy, there are alterations in the number, phenotype and …

The presence of persistent intrathecal oligoclonal immunoglobulin G (IgG) bands (OCBs)
and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease …

Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous
system. Immune cell features are particularly promising as predictive biomarkers due to their …

Multiple sclerosis is associated with Epstein–Barr virus (EBV) infection, B‐cell dysfunction,
gut dysbiosis, and environmental and genetic risk factors, including female sex. A disease …

Understanding the immune profile of acute rheumatic fever (ARF), a serious post-infectious
sequelae of Streptococcal pyogenes (group A Streptococcus [GAS]), could inform disease …

Current understanding of Multiple Sclerosis (MS) pathophysiology implicates perturbations
in adaptive cellular immune responses, predominantly T cells, in Relapsing-Remitting forms …