MEN1 mutations mediate clinical resistance to menin inhibition
Chromatin-binding proteins are critical regulators of cell state in haematopoiesis,. Acute
leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2A r) or …
leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2A r) or …
[HTML][HTML] Childhood Multiple Endocrine Neoplasia (MEN) Syndromes: Genetics, Clinical Heterogeneity and Modifying Genes
F Lanzaro, D De Biasio, FG Cesaro… - Journal of Clinical …, 2024 - mdpi.com
Multiple endocrine neoplasia (MEN) syndromes are part of a spectrum of clinically well-
defined tumor syndromes ultimately characterized by histologically similar tumors arising in …
defined tumor syndromes ultimately characterized by histologically similar tumors arising in …
[HTML][HTML] Bioinformatics Study on Site-Specific Variations of Eotaxin-3, a Key Chemokine in Eosinophilic Esophagitis (EoE)
Eotaxin-3 is a key chemokine with a relevant role in eosinophilic esophagitis, a rare chronic
immune/antigen-mediated inflammatory disorder. Eotaxin-3 is a potent activator of …
immune/antigen-mediated inflammatory disorder. Eotaxin-3 is a potent activator of …
Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular …
KMA Dreijerink, E Ozyerli-Goknar, S Koidl… - Epigenetics & …, 2022 - Springer
Background Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1)
gene are causal to the MEN1 tumor syndrome, but they are also commonly found in …
gene are causal to the MEN1 tumor syndrome, but they are also commonly found in …
Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein–protein interactions
Protein–protein interactions (PPIs) play a critical role in all biological processes. Menin is
tumor suppressor protein, mutated in multiple endocrine neoplasia type 1 syndrome and has …
tumor suppressor protein, mutated in multiple endocrine neoplasia type 1 syndrome and has …
[HTML][HTML] Design of Inhibitors That Target the Menin–Mixed-Lineage Leukemia Interaction
The prognosis of mixed-lineage leukemia (MLL) has remained a significant health concern,
especially for infants. The minimal treatments available for this aggressive type of leukemia …
especially for infants. The minimal treatments available for this aggressive type of leukemia …
A Novel Pathogenic MEN1 Gene Variant Identified in a Family With Multiple Pancreatic Neuroendocrine Tumors
H Horikoshi, J Arita, K Hasegawa… - JCEM Case …, 2023 - academic.oup.com
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine tumor syndrome
caused by pathogenic variants in the MEN1 gene, and most patients with this syndrome …
caused by pathogenic variants in the MEN1 gene, and most patients with this syndrome …
A computational study of structural analysis of Class I human glucose-6-phosphate dehydrogenase (G6PD) variants: Elaborating the correlation to chronic non …
Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common
human enzyme defect that affects more than 500 million people worldwide. Individuals …
human enzyme defect that affects more than 500 million people worldwide. Individuals …
In silico analysis of the effects of omicron spike amino acid changes on the interactions with human proteins
N D'Arminio, D Giordano, B Scafuri, C Biancaniello… - Molecules, 2022 - mdpi.com
The SARS-CoV-2 variant Omicron is characterized, among others, by more than 30 amino
acid changes occurring on the spike glycoprotein with respect to the original SARS-CoV-2 …
acid changes occurring on the spike glycoprotein with respect to the original SARS-CoV-2 …
Molecular mechanisms of dynamics-mediated effects of pathogenic missense mutations on Menin protein function
Q Zhang, H Wang, X Chen, W Li, J Peng, M Zhang… - bioRxiv, 2024 - biorxiv.org
Understanding how disease-causing missense mutations (DCMMs) affect protein function is
fundamental. The traditional structure-function paradigm for proteins has evolved into a …
fundamental. The traditional structure-function paradigm for proteins has evolved into a …