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Changing views of the pathophysiology of Parkinsonism
T Wichmann - Movement Disorders, 2019 - Wiley Online Library
Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia)
have a long history and primarily model the consequences of dopamine loss in the basal …
have a long history and primarily model the consequences of dopamine loss in the basal …
The supplementary motor complex in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and
nonmotor symptoms. Although the basal ganglia is traditionally the primary brain region …
nonmotor symptoms. Although the basal ganglia is traditionally the primary brain region …
Parkinsonism alters beta burst dynamics across the basal ganglia–motor cortical network
Elevated synchronized oscillatory activity in the beta band has been hypothesized to be a
pathophysiological marker of Parkinson's disease (PD). Recent studies have suggested that …
pathophysiological marker of Parkinson's disease (PD). Recent studies have suggested that …
[HTML][HTML] Directional deep brain stimulation leads reveal spatially distinct oscillatory activity in the globus pallidus internus of Parkinson's disease patients
The goal of this study was to characterize the spectral characteristics and spatial topography
of local field potential (LFP) activity in the internal segment of the globus pallidus (GPi) in …
of local field potential (LFP) activity in the internal segment of the globus pallidus (GPi) in …
Asthma's effect on brain connectivity and cognitive decline
T Wang, X Huang, J Wang - Frontiers in Neurology, 2023 - frontiersin.org
Objective To investigate the changes in dynamic voxel mirror homotopy connection
(dVMHC) between cerebral hemispheres in patients with asthma. Methods Our study was …
(dVMHC) between cerebral hemispheres in patients with asthma. Methods Our study was …
Ventral tegmental area connections to motor and sensory cortical fields in humans
In humans, sensorimotor cortical areas receive relevant dopaminergic innervation—
although an anatomic description of the underlying fiber projections is lacking so far. In …
although an anatomic description of the underlying fiber projections is lacking so far. In …
Proceedings of the sixth deep brain stimulation think tank modulation of brain networks and application of advanced neuroimaging, neurophysiology, and …
The annual deep brain stimulation (DBS) Think Tank aims to create an opportunity for a
multidisciplinary discussion in the field of neuromodulation to examine developments …
multidisciplinary discussion in the field of neuromodulation to examine developments …
Modulation of neural activity for myelination in the central nervous system
Electrical stimulation has been playing a significant role in revealing various functions and
mechanisms of the nervous system. It is no different for myelination, a process in which …
mechanisms of the nervous system. It is no different for myelination, a process in which …
Parkinsonism disrupts neuronal modulation in the pre-supplementary motor area during movement preparation
CM Hendrix, HE Baker, Y Yu, DD Schneck… - Journal of …, 2025 - jneurosci.org
Multiple studies suggest that Parkinson's disease (PD) is associated with changes in
neuronal activity throughout the basal ganglia-thalamocortical motor circuit. There are …
neuronal activity throughout the basal ganglia-thalamocortical motor circuit. There are …
Reward-driven enhancements in motor control are robust to TMS manipulation
A wealth of evidence describes the strong positive impact that reward has on motor control
at the behavioural level. However, surprisingly little is known regarding the neural …
at the behavioural level. However, surprisingly little is known regarding the neural …