Toward the solution of the protein structure prediction problem
Since Anfinsen demonstrated that the information encoded in a protein's amino acid
sequence determines its structure in 1973, solving the protein structure prediction problem …
sequence determines its structure in 1973, solving the protein structure prediction problem …
Deep learning in proteomics
Proteomics, the study of all the proteins in biological systems, is becoming a data‐rich
science. Protein sequences and structures are comprehensively catalogued in online …
science. Protein sequences and structures are comprehensively catalogued in online …
Folding non-homologous proteins by coupling deep-learning contact maps with I-TASSER assembly simulations
Structure prediction for proteins lacking homologous templates in the Protein Data Bank
(PDB) remains a significant unsolved problem. We developed a protocol, CI-TASSER, to …
(PDB) remains a significant unsolved problem. We developed a protocol, CI-TASSER, to …
High‐accuracy protein structure prediction in CASP14
The application of state‐of‐the‐art deep‐learning approaches to the protein modeling
problem has expanded the “high‐accuracy” category in CASP14 to encompass all targets …
problem has expanded the “high‐accuracy” category in CASP14 to encompass all targets …
Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences
In the field of artificial intelligence, a combination of scale in data and model capacity
enabled by unsupervised learning has led to major advances in representation learning and …
enabled by unsupervised learning has led to major advances in representation learning and …
Accurate de novo prediction of protein contact map by ultra-deep learning model
Motivation Protein contacts contain key information for the understanding of protein structure
and function and thus, contact prediction from sequence is an important problem. Recently …
and function and thus, contact prediction from sequence is an important problem. Recently …
Clustering huge protein sequence sets in linear time
Metagenomic datasets contain billions of protein sequences that could greatly enhance
large-scale functional annotation and structure prediction. Utilizing this enormous resource …
large-scale functional annotation and structure prediction. Utilizing this enormous resource …
Critical assessment of methods of protein structure prediction (CASP)—Round XII
This article reports the outcome of the 12th round of Critical Assessment of Structure
Prediction (CASP12), held in 2016. CASP is a community experiment to determine the state …
Prediction (CASP12), held in 2016. CASP is a community experiment to determine the state …
Toward the estimation of the absolute quality of individual protein structure models
Motivation: Quality assessment of protein structures is an important part of experimental
structure validation and plays a crucial role in protein structure prediction, where the …
structure validation and plays a crucial role in protein structure prediction, where the …