The burden and risks of emerging complications of diabetes mellitus

D Tomic, JE Shaw, DJ Magliano - Nature Reviews Endocrinology, 2022 - nature.com
The traditional complications of diabetes mellitus are well known and continue to pose a
considerable burden on millions of people living with diabetes mellitus. However, advances …

Neurobiology of early life adversity: A systematic review of meta-analyses towards an integrative account of its neurobiological trajectories to mental disorders

Y Hakamata, Y Suzuki, H Kobashikawa… - Frontiers in …, 2022 - Elsevier
Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of develo** mental disorders in later life. However, no review has …

The effects of childhood maltreatment on brain structure, function and connectivity

MH Teicher, JA Samson, CM Anderson… - Nature reviews …, 2016 - nature.com
Maltreatment-related childhood adversity is the leading preventable risk factor for mental
illness and substance abuse. Although the association between maltreatment and …

The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology

EL Belleau, MT Treadway, DA Pizzagalli - Biological psychiatry, 2019 - Elsevier
Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Brain structure alterations in depression: Psychoradiological evidence

FF Zhang, W Peng, JA Sweeney… - CNS neuroscience & …, 2018 - Wiley Online Library
Depression is the leading cause of disability around the world, but little is known about its
pathology. Currently, the diagnosis of depression is made based on clinical manifestations …

Annual research review: enduring neurobiological effects of childhood abuse and neglect

MH Teicher, JA Samson - Journal of child psychology and …, 2016 - Wiley Online Library
Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression

C Fan, Y Li, T Lan, W Wang, Y Long, SY Yu - Molecular Therapy, 2022 - cell.com
Enhancing neurogenesis within the hippocampal dentate gyrus (DG) is critical for
maintaining brain development and function in many neurological diseases. However, the …

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

MJF Levy, F Boulle, HW Steinbusch… - …, 2018 - Springer
Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Exercise effects on depression: Possible neural mechanisms

S Gujral, H Aizenstein, CF Reynolds III… - General hospital …, 2017 - Elsevier
Depression is a syndrome of stress-and emotion-dysregulation, involving compromised
structural integrity of frontal-limbic networks. Meta-analytic evidence indicates that volumetric …

The hippocampus in depression: more than the sum of its parts? Advanced hippocampal substructure segmentation in depression

DW Roddy, C Farrell, K Doolin, E Roman, L Tozzi… - Biological …, 2019 - Elsevier
Background Hippocampal volume reduction is the most replicated finding in neuroimaging
studies of major depressive disorder (MDD). Varying hippocampal volume definition is a …