Toxicity of nanomaterials
Nanoscience has matured significantly during the last decade as it has transitioned from
bench top science to applied technology. Presently, nanomaterials are used in a wide …
bench top science to applied technology. Presently, nanomaterials are used in a wide …
Bone-targeted nanoparticle drug delivery system: an emerging strategy for bone-related disease
Targeted delivery by either systemic or local targeting of therapeutics to the bone is an
attractive treatment for various bone metabolism diseases such as osteoporosis …
attractive treatment for various bone metabolism diseases such as osteoporosis …
[HTML][HTML] Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone …
The design of orthopedic biomaterials has gradually shifted from “immune-friendly” to
“immunomodulatory,” in which the biomaterials are able to modulate the inflammatory …
“immunomodulatory,” in which the biomaterials are able to modulate the inflammatory …
[HTML][HTML] Bisphosphonate conjugation for bone specific drug targeting
KB Farrell, A Karpeisky, DH Thamm, S Zinnen - Bone reports, 2018 - Elsevier
Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …
Osteoimmunomodulatory nanoparticles for bone regeneration
Treatment of large bone fractures remains a challenge for orthopedists. Bone regeneration
is a complex process that includes skeletal cells such as osteoblasts, osteoclasts, and …
is a complex process that includes skeletal cells such as osteoblasts, osteoclasts, and …
Synthesis of lactoferrin mesoporous silica nanoparticles for pemetrexed/ellagic acid synergistic breast cancer therapy
Despite the clinical approval of few nanomedicines for cancer therapy, some drawbacks still
impede their improved efficiency including low drug loading, off-target toxicity and …
impede their improved efficiency including low drug loading, off-target toxicity and …
Nanomedicines for the treatment of hematological malignancies
AK Deshantri, AV Moreira, V Ecker… - Journal of Controlled …, 2018 - Elsevier
Hematological malignancies (HM) are a collection of malignant transformations originating
from cells in the primary or secondary lymphoid organs. Leukemia, lymphoma, and multiple …
from cells in the primary or secondary lymphoid organs. Leukemia, lymphoma, and multiple …
Targeted delivery to bone and mineral deposits using bisphosphonate ligands
The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …
compared with all other tissues and thus provides opportunity for targeted delivery of …
Interactions of PLGA nanoparticles with blood components: protein adsorption, coagulation, activation of the complement system and hemolysis studies
The intravenous administration of poly (lactic-co-glycolic) acid (PLGA) nanoparticles has
been widely reported as a promising alternative for delivery of drugs to specific cells …
been widely reported as a promising alternative for delivery of drugs to specific cells …
Biomedical applications of bisphosphonates
Since their discovery over 100years ago, bisphosphonates have been used industrially as
corrosion inhibitors and complexing agents. With the discovery of their pharmacological …
corrosion inhibitors and complexing agents. With the discovery of their pharmacological …