Human immunology through the lens of evolutionary genetics

L Quintana-Murci - Cell, 2019 - cell.com
Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

Middle to late holocene paleoclimatic change and the early bantu expansion in the rain forests of Western Central Africa

K Bostoen, B Clist, C Doumenge… - Current …, 2015 - journals.uchicago.edu
This article reviews evidence from biogeography, palynology, geology, historical linguistics,
and archaeology and presents a new synthesis of the paleoclimatic context in which the …

High-depth African genomes inform human migration and health

A Choudhury, S Aron, LR Botigué, D Sengupta… - Nature, 2020 - nature.com
The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …

[HTML][HTML] Genetic adaptation and neandertal admixture shaped the immune system of human populations

H Quach, M Rotival, J Pothlichet, YHE Loh… - Cell, 2016 - cell.com
Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the
extent of population differences in immune responses and their genetic and evolutionary …

The African genome variation project shapes medical genetics in Africa

D Gurdasani, T Carstensen, F Tekola-Ayele, L Pagani… - Nature, 2015 - nature.com
Given the importance of Africa to studies of human origins and disease susceptibility,
detailed characterization of African genetic diversity is needed. The African Genome …

Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

E Patin, M Lopez, R Grollemund, P Verdu, C Harmant… - Science, 2017 - science.org
Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-
speaking populations remains largely unexplored. We generated genomic data for 1318 …

Uganda genome resource enables insights into population history and genomic discovery in Africa

D Gurdasani, T Carstensen, S Fatumo, G Chen… - Cell, 2019 - cell.com
Genomic studies in African populations provide unique opportunities to understand disease
etiology, human diversity, and population history. In the largest study of its kind, comprising …

Genomic perspectives on human dispersals during the Holocene

M Stoneking, L Arias, D Liu, S Oliveira… - Proceedings of the …, 2023 - National Acad Sciences
Nearly 20 y ago, Jared Diamond and Peter Bellwood reviewed the evidence for the
associated spread of farming and large language families by the demographic expansions …

Inferring population size history from large samples of genome-wide molecular data-an approximate Bayesian computation approach

S Boitard, W Rodríguez, F Jay, S Mona… - PLoS genetics, 2016 - journals.plos.org
Inferring the ancestral dynamics of effective population size is a long-standing question in
population genetics, which can now be tackled much more accurately thanks to the massive …

Tales of human migration, admixture, and selection in Africa

CM Schlebusch, M Jakobsson - Annual Review of Genomics …, 2018 - annualreviews.org
In the last three decades, genetic studies have played an increasingly important role in
exploring human history. They have helped to conclusively establish that anatomically …