Structural insights into the functional diversity of the CDK–cyclin family
DJ Wood, JA Endicott - Open biology, 2018 - royalsocietypublishing.org
Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …
New insights into protein–protein interaction modulators in drug discovery and therapeutic advance
Protein-protein interactions (PPIs) are fundamental to cellular signaling and transduction
which marks them as attractive therapeutic drug development targets. What were once …
which marks them as attractive therapeutic drug development targets. What were once …
A central chaperone-like role for 14-3-3 proteins in human cells
D Segal, S Maier, GJ Mastromarco, WW Qian… - Molecular cell, 2023 - cell.com
3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …
Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation
Pyrin, encoded by the MEFV gene, is best known for its gain-of-function mutations causing
familial Mediterranean fever (FMF), an autoinflammatory disease. Pyrin forms a caspase-1 …
familial Mediterranean fever (FMF), an autoinflammatory disease. Pyrin forms a caspase-1 …
Reversible dual-covalent molecular locking of the 14-3-3/ERRγ protein–protein interaction as a molecular glue drug discovery approach
BA Somsen, RJC Schellekens… - Journal of the …, 2023 - ACS Publications
Molecules that stabilize protein–protein interactions (PPIs) are invaluable as tool
compounds for biophysics and (structural) biology, and as starting points for molecular glue …
compounds for biophysics and (structural) biology, and as starting points for molecular glue …
14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides
Abstract Motivation: The 14-3-3 family of phosphoprotein-binding proteins regulates many
cellular processes by docking onto pairs of phosphorylated Ser and Thr residues in a …
cellular processes by docking onto pairs of phosphorylated Ser and Thr residues in a …
The role of 14-3-3 proteins in plant growth and response to abiotic stress
Y Huang, W Wang, H Yu, J Peng, Z Hu, L Chen - Plant Cell Reports, 2022 - Springer
Abstract The 14-3-3 proteins widely exist in almost all plant species. They specifically
recognize and interact with phosphorylated target proteins, including protein kinases …
recognize and interact with phosphorylated target proteins, including protein kinases …
[HTML][HTML] Pyrenoids: CO2-fixing phase separated liquid organelles
Pyrenoids are non-membrane bound organelles found in chloroplasts of algae and hornwort
plants that can be seen by light-microscopy. Pyrenoids are formed by liquid-liquid phase …
plants that can be seen by light-microscopy. Pyrenoids are formed by liquid-liquid phase …
[HTML][HTML] The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins
KV Tugaeva, DEDP Hawkins, JLR Smith… - Journal of Molecular …, 2021 - Elsevier
The coronavirus nucleocapsid protein (N) controls viral genome packaging and contains
numerous phosphorylation sites located within unstructured regions. Binding of …
numerous phosphorylation sites located within unstructured regions. Binding of …
14-3-3 proteins in brain development: neurogenesis, neuronal migration and neuromorphogenesis
B Cornell, K Toyo-Oka - Frontiers in molecular neuroscience, 2017 - frontiersin.org
The 14-3-3 proteins are a family of highly conserved, multifunctional proteins that are highly
expressed in the brain during development. Cumulatively, the seven 14-3-3 isoforms make …
expressed in the brain during development. Cumulatively, the seven 14-3-3 isoforms make …