Background: High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-
cTnT) in individuals with no clinically manifest myocardial injury. Objectives: The goal of this …

A central factor in the pathogenesis of heart failure (HF) with reduced ejection fraction is the
initial decrease in systolic function. Prior attempts at increasing cardiac contractility with oral …

Background Impaired contractility is a feature of heart failure with reduced ejection fraction.
We assessed the pharmacokinetics and effects on cardiac function and structure of the …

Abstract The International Federation of Clinical Chemistry Committee on Clinical
Application of Cardiac Bio-Markers provides evidence-based educational documents to …

Cardiac troponins (cTns) I and T have long been the most successful cardiac-specific
circulating biomarkers in cardiovascular (CV) medicine, having changed dramatically the …

Modern laboratory methods for determining biomarkers of cardiovascular diseases are
highly sensitive and can detect almost single molecules in human biological fluids …

Background: There is a paucity of data on the association between high-sensitivity cardiac
troponin (hs-cTn) levels and outcomes in patients with chest pain but no myocardial …

The morbidity and mortality rates for acute myocardial infarction (AMI) have been growing
rapidly in the recent years, causing a significant socio-economic damage. The cardiospecific …

Methods for the determination of cardiac troponins have been significantly improved,
facilitating further advancement of the therapeutic and diagnostic process of the …

BACKGROUND Interpretation of serial high-sensitivity cardiac troponin (hs-cTn)
measurements for the diagnosis of acute myocardial infarction (AMI) assumes random …