The gut flora as a forgotten organ

AM O'Hara, F Shanahan - EMBO reports, 2006 - embopress.org
The intestinal microflora is a positive health asset that crucially influences the normal
structural and functional development of the mucosal immune system. Mucosal immune …

Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion

GN Schroeder, H Hilbi - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless
enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research …

A bacterial effector acts as a plant transcription factor and induces a cell size regulator

S Kay, S Hahn, E Marois, G Hause, U Bonas - Science, 2007 - science.org
Pathogenicity of many Gram-negative bacteria relies on the injection of effector proteins by
type III secretion into eukaryotic cells, where they modulate host signaling pathways to the …

Gut microbiota: a potential new territory for drug targeting

W Jia, H Li, L Zhao, JK Nicholson - Nature reviews Drug discovery, 2008 - nature.com
The significant involvement of the gut microbiota in human health and disease suggests that
manipulation of commensal microbial composition through combinations of antibiotics …

Commensal gut bacteria: mechanisms of immune modulation

D Kelly, S Conway, R Aminov - Trends in immunology, 2005 - cell.com
Mucosal immune responses to pathogenic gut bacteria and the mechanisms that govern
disease progression and outcome have been researched intensely for decades. More …

Type III secretion: building and operating a remarkable nanomachine

AG Portaliou, KC Tsolis, MS Loos, V Zorzini… - Trends in biochemical …, 2016 - cell.com
The Type III secretion system (T3SS) is a protein export pathway that is widespread in Gram-
negative bacteria and delivers effector proteins directly into eukaryotic cells. At its core lie …

Enteropathogenic and Enterohemorrhagic Escherichia coli Infections: Translocation, Translocation, Translocation

J Garmendia, G Frankel, VF Crepin - Infection and immunity, 2005 - Am Soc Microbiol
Escherichia coli is the most abundant facultative anaerobic gram-negative bacterium of the
intestinal microffora, naturally colonizing the mucous layer of the colon. A conserved core …

Insights into Genome Plasticity and Pathogenicity of the Plant Pathogenic Bacterium Xanthomonas campestris pv. vesicatoria Revealed by the Complete Genome …

F Thieme, R Koebnik, T Bekel, C Berger… - Journal of …, 2005 - Am Soc Microbiol
The gram-negative plant-pathogenic bacterium Xanthomonas campestris pv. vesicatoria is
the causative agent of bacterial spot disease in pepper and tomato plants, which leads to …

Proteinaceous determinants of surface colonization in bacteria: bacterial adhesion and biofilm formation from a protein secretion perspective

C Chagnot, MA Zorgani, T Astruc… - Frontiers in …, 2013 - frontiersin.org
Bacterial colonization of biotic or abiotic surfaces results from two quite distinct physiological
processes, namely bacterial adhesion and biofilm formation. Broadly speaking, a biofilm is …

Bacterial nanomachines: the flagellum and type III injectisome

M Erhardt, K Namba… - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The bacterial flagellum and the virulence-associated injectisome are complex, structurally
related nanomachines that bacteria use for locomotion or the translocation of virulence …