Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
characterized by poor treatment response and low survival time. The current clinical …

Simple Summary Pancreatic cancer has a dismal 5-year survival rate of 10%, making it one
of the deadliest forms of malignancy. The poor prognosis associated with this disease is …

Pancreatic ductal adenocarcinoma (PDAC) is a highly life-threatening tumour with a low
early-detection rate, rapid progression and a tendency to develop resistance to …

Resistance to gemcitabine is the main challenge of chemotherapy for pancreatic ductal
adenocarcinoma (PDAC). Hence, the development of a response signature to gemcitabine …

Gemcitabine (GEM) is the first-line medication for pancreatic ductal adenocarcinoma
(PDAC). However, over some treatment cycles, GEM sensitivity declines and …

Simple Summary The PI3K/AKT pathway is one of the most important signaling nodes in
cancer. While class I PI3K roles in cancer are well known, class II and III functions in …

Neuronal nerve processes in the tumor microenvironment were highlighted recently.
However, the origin of intra-tumoral nerves remains poorly known, in part because of …